Fondazione Ricerca e Innovazione Cardiovascolare and Fundación EPIC Launch PICCOLETO IV-EPIC Clinical Trial

Italian-Spanish collaboration advances interventional cardiology research through landmark multicenter study

Milan, Italy — Fondazione Ricerca e Innovazione Cardiovascolare ETS(Fondazione RIC), a leading independent non-profit research foundation at the forefront of cardiovascular innovation, in collaboration with Fundación EPIC (Educación en Procedimientos de Intervencionismo en Cardiología), Spain’s premier foundation dedicated to excellence in interventional cardiology education and research, proudly announces the official launch of the PICCOLETO IV clinical trial at Auxologico Research Hospital, Milan, Italy.

PICCOLETO IV is an international multicenter, investigator-driven, open-label, randomized (1:1), clinical investigation designed to observe and evaluate the rate of ischemic and bleeding adverse events of a single antiplatelet regimen (SAPT) since the time of PCI with latest generation DCB in elderly or high bleeding risk population with stable or unstable coronary syndromes. The study will enroll approximately 576 patients across 20 centers in 4 countries (Spain, Italy, Belgium, and Luxembourg), with a planned follow-up period of 12 months.